What are the registry database disadvantages using a registry cleaner?

The biggest disadvantage of Registry Cleaners is their weak distinction feature. Some Registry Cleaners fail to rate severity of errors and those succeeded erroneously categorized errors as critical without giving proper reason of categorization.

What are the limitations of Installing Registry Cleaners:

Critics often claim that there is no authentic way of knowing whether a third party application has an invalid key, redundant information or not.

Inefficient and poorly crafted Registry Cleaners could not make distinction between used and unused key for Windows. It could not assess the detrimental effects of removing used key from computer.

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The abovementioned flaw in Registry Cleaners create some worrisome situation such as malfunctioning of system, loss of functionality and accessing Microsofts application compatibility updates to prevent harmful Registry Cleaners.

Registry Cleaners fail to redeem scenarios like undeletable registry keys that occurred due to insertion of null characters in their names. However, there are few specialized tools available in the market, like RegDelNull utility and Sysinternals (now Microsoft), which could redeem such kinds of scenarios.

Potential to Recover:

Registry Cleaner fails to repair those Registry hives that couldnt be mounted by the system.

Despite all these problems, a corrupt registry can be recovered in several ways supported by Microsoft. For instance Automated System Recovery by using System Restore or by running setup from the Last Known Good boot menu.

Malware elimination:

Despite all these problems, a corrupt registry can be recovered in several ways supported by Microsoft. For instance Automated System Recovery by using System Restore or by running setup from the Last Known Good boot menu.

Registry Cleaners fail to detect or delete Registry entries linked with a rootkit that can conceal this information from other processes.

To draw a comparison between the results of Registry API and raw underlying Registry storage, a specialized tool is required.

Do Registry Cleaners work in application virtualization scenario?

Registry Cleaners could not remove those Registry entries which are written for a virtualized application.